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These agents include cyclosporine, cyclophosphamide, methotrexate, mycophenolate mofetil, oral tacrolimus, intravenous immunoglobulin (IVIg), dapsone, colchicine, plasmapheresis, hydroxychloroquine, warfarin, omalizumab, and so on.

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Furthermore, only the surviving patients with the dapsone hypersensitivity syndrome were recruited in this study as the case patients; their symptoms are likely to have been relatively mild as compared with those of patients with the dapsone hypersensitivity syndrome who died before sample collection.

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Some subjects experienced changes in hemoglobin during both treatments, and some subjects had very low or unmeasurable plasma levels of dapsone.

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In contast, humans are not affected by this inhibition of folate synthesis because they rely upon dietary sources of folate.

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Treatment with thyroxine has been reported to alleviate the urticaria.

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To identify the genetic risk factors for the dapsone hypersensitivity syndrome, we performed a genomewide association study in the Chinese population, comparing patients with leprosy in whom the dapsone hypersensitivity syndrome developed after the initiation of treatment (case patients) with those in whom the syndrome did not develop (controls).

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Of the 10 patients who showed clinical or total remission, 10 (100%) had been treated with prednisone, 7 (70%) with cyclophosphamide, 3 (30%) with azathioprine, 3 (30%) with dapsone, 2 (20%) with minocycline, and 1 (10%) had plasmapheresis.

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